子宮頸癌的疫苗在全球已經上市十多年,理論上可以預防子宮頸癌 ,但還未有大型研究結果 。前幾天在新英格蘭醫學雜誌上發表了一份在瑞典160萬名年輕女性接種4價HPV 疫苗12年的追蹤研究報告。下方的圖表裡,很清楚的表示了有無接種疫苗與各年齡層子宮頸癌的發生頻率。
17歲以前接種疫苗的女性在12年的追蹤過程中發生子宮頸癌的機率,在調整可能偏見的變因過後,大約是不到未接種疫苗女性機率的3-4成,這相當於之前預測的結果,身爲婦產科醫師的我對這個結果其實並不感到驚訝,因為四價疫苗涵蓋的病毒株大約佔所有子宮頸癌病毒株的6-7成。
這個疫苗的發展從找到HPV 病毒為主要致癌機轉(99.7%),到發展出全球疫苗造福所有女性,是醫學研究的一大勝利。這張圖表勝過千言萬語,值得與大家分享。
註)
4 價疫苗比2價多兩型可以多預防病毒疣。
9 價疫苗除了以上還包括一些在亞洲與台灣流行的其他致癌株 可以達到近9成涵蓋率。
圖中子宮頸癌好發的年齡開始在23歲其實是因爲瑞典在這個年齡開始健保抹片檢查但以直線回推確實22歲之前子宮頸癌發生率非常小。
在這份研究裡,50萬位接種疫苗的女性裡仍有19位女性在追蹤過程不幸得到子宮頸癌,所以疫苗不是100%的預防。
目前我國疫苗接種情況良好,國一即可施打2價的公費疫苗,但仍建議30歲以上女性或有性行為三年以上年輕女性,定期做子宮頸抹片檢查。
#HPV疫苗真的有效
#6分鐘仍會護一生
The human papilloma virus (HPV) vaccine for prevention of cervical cancer has been around for more than a decade. The result of a 12-year follow-up study on a 1.6 million Swedish cohort was published last week in the New England Journal of Medicine. The graph below speaks more than a thousand words about the importance of HPV vaccination for women.
The cumulative incidence of cervical cancer in women who received vaccination before the age of 17 is approximately half of those who never received vaccination. After adjustment of covariate, the incidence ratio is about 0.37. This result does not surprise me because the HPV vaccine covers serotype 16 and 18 which cause up to 70% of all cervical cancer.
We have come a long way since the discovery of the association between HPV and cervical cancer as early as the 60's to the invention of HPV vaccine in the early 2000's. This fabulous result of cancer reduction from a vaccination program in a large scale population is an example of medical innovation and collaboration. I would not be surprised if another Nobel Laureate is crowned on a scientist working in this area in the near future (such as the distinguished Australian, Professor Ian Frazer. )
p.s.
the quadrivalent vaccine is better than the double-valent because it also covers some serotypes that cause genital warts.
the 9-valent vaccine also includes carcinogenic serotypes that are common in Asia.
the incidence of cervical cancer begins to rise at age of 23, this reflects the starting age of pap smear program in Sweden. However, the incidence of cervical cancer before age of 23 is ver low.
there are still 19 women who developed cervical cancer out of the half-million women who received HPV vaccination, so vaccination does not offer 100% protection
There is a high rate of vaccination uptake in Taiwan. However, it is still important to do pap smear regularly for women over 30 or those who are sexually active for more than 3 years.
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[Sweden - Malmö]
不經不覺又四年,當初一個月周圍遊到尾聲,打算與友人由丹麥哥本哈根出發回到瑞典,但在三月中那時直接飛回首都並非最便宜的方法
反正還有時間,決定搭巴士先到Malmö 馬爾默轉個圈,逛逛這個怡情小鎮
https://timjaieat.blogspot.com/p/sweden.html#malmo
Music: Adam Selzer - Loves Me
#timjaieat #timjaitravel #timjaiinsweden
VisitSweden 馬爾摩 The Local Sweden Study in Sweden Sweden.se WS Lee
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交通大學109學年度第一梯次出國交換展
NCTU Exchange Abroad Fair for AY20/21 (1st Intake)
日期: 2019/11/22 (Friday)
時間: 11:00-17:00
地點: 交通大學圖書館 Library B1
※請出示學生證參加 Please show your student ID to participate
本次展覽包含攤位及講座兩部份。本處邀請14間姊妹校代表設置攤位,包含:
There are two parts to this fair.
Part One – Booth:
1. Sweden - Chalmers University of Technology 查默斯理工大學
2. Finland - Hanken School of Economics 漢肯經濟學院
3. Finland - University of Jyvaskyla 約瓦斯其拉大學
4. Singapore - Singapore University of Technology and Design 新加坡科技與設計大學
5. Hong Kong - Hong Kong University of Science and Technology 香港科技大學
6. France - École Polytechnique 巴黎綜合理工學院
7. France - University of Technology of Troyes 特魯瓦科技大學
8. France - Ecole Internationale des Sciences du Traitement de l’Information (EISTI) 信息處理科學國際學院
9. France - Sup'Biotech Paris 生物技術高等學院
10. Japan - Waseda University 早稻田大學
11. Israel - Technion - Israel Institute of Technology 以色列理工學院
12. Germany - University of Augsburg 奧格斯堡大學
13. Netherlands - University of Twente 湍特大學
14. Belgium - KU Leuven 天主教荷語魯汶大學
上述知名姊妹校將為本地學生介紹國外學習環境與生活文化等,現場接受學生諮詢,提供最一手之交換資訊。
Above world renowned partner institutions will introduce their study environment, living and culture to our local students. They will also answer questions and provide first-hand information on exchange studies to our students.
Part Two – Information Session:
除各校攤位外,本處也於當天出國交換說明會,向同學解說申請出國交換流程及注意事項等:
Besides having booths, several information sessions have also been arranged:
12:20-13:10 Session 1 109學年度第一梯次出國交換計畫說明
Introduction to AY20/21 Outbound Exchange Program (1st Intake)
<報名連結>
https://docs.google.com/forms/d/e/1FAIpQLSf1sEVqotxTOQ_ORDiVJqcEO8DDzUjoX8Jfh6kv5oRPAPgnMA/viewform
13:20-14:10 Session 2A Study at Chalmers University
Session 2B JYU Serving the Future since 1863
14:20-15:10 Session 3A Waseda University Information Session
Session 3B What is École Polytechnique's Brand New Bachelor Program? A talk by a first-generation student
15:30-16:20 Session 4A Presentation of the UTT
Session 4B Study in the Netherlands - from an Asian Student’s Perspective
此外,為鼓勵學生踴躍參加,符合以下所有條件者,於申請109學年度第一梯次出國交換校內甄選時,可將「出國交換展參加證明」納入其他有利審查文件中:
1. 諮詢8個(含)以上姐妹校/國際處攤位
2. 參加2個(含)以上講座
To encourage students to participate in this event, if you fulfill below requirement, your certificate of participation can be used as one of the supporting document when you apply to AY20/21 Outbound Exchange Program:
1. Consult with 8 or more booths
2. Attend 2 or more information sessions
本活動網頁公告 Announcement of this event
109學年度第一梯次出國交換計畫公告 Announcement of AY20/21 Outbound Exchange Program (1st Intake)
https://oia.nctu.edu.tw/announcement/student-area/6929/
承辦人 Contact Person:國際事務處 周秋儀 OIA - Ms. Cherrie CHOW
校內分機 Extension:50059
cherrie@nctu.edu.tw
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